Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. Cymbalta can increase serotonin levels in your body. Using Cymbalta with other drugs that also increase serotonin may raise your risk for serotonin syndrome.
Serotonin syndrome is a rare but potentially life threatening condition. Taking multiple medications that increase serotonin levels could cause serotonin to build up to dangerous levels in your blood. Before taking Cymbalta, be sure to tell your doctor if you take any of the medications listed above. They may want to monitor you for any signs of serotonin syndrome. Or they may have you take a different drug to treat your condition. Taking Cymbalta with these drugs may increase Cymbalta levels in your body.
Slowing down this process could raise your risk for side effects from Cymbalta. Certain drugs have stronger effects on these enzymes.
Examples of strong CYP1A2 inhibitors include:. Examples of CYP2D6 inhibitors include:. Before you take Cymbalta, be sure to tell your doctor if you take any of these medications.
They can determine which drug is the best fit for you. This means it can affect the levels of other drugs that are also broken down by this enzyme. However, some medications can cause side effects if their levels in your body are changed slightly.
Examples of these drugs include:. Before taking Cymbalta, talk with your doctor about all the medications you take. They can determine whether Cymbalta can be taken with your other medications. Drugs that affect serotonin levels, such as Cymbalta, may increase your risk for bleeding. Before taking Cymbalta, tell your doctor if you take any of the medications listed above. This monitoring may include ordering blood tests. Or they may decide to use a different medication to treat your condition.
This is an herb that can be used to treat depression. Cymbalta can raise your serotonin levels. Because St. If you have any questions about eating certain foods with Cymbalta, talk with your doctor. Clinical studies of the drug have shown that taking it the month before delivery may increase the risk of severe bleeding immediately afterward postpartum hemorrhage.
The manufacturer of Cymbalta maintains a pregnancy registry. The registry tracks the results of pregnant people taking the drug. You can join this registry online or by calling You should also tell your doctor right away if you become pregnant while taking this drug. You can take Cymbalta at any time of the day. However, you should try to take it around the same time every day. This helps make sure you have a consistent amount of the drug in your body.
The best time for you to take Cymbalta may depend on what you use the drug for and how often you take it each day. Your doctor can help you decide the best time for you to take Cymbalta. Doing so may affect how well your body absorbs the drug. This could raise your risk for side effects or make the drug less effective.
You can also call the American Association of Poison Control Centers at or use their online tool. But if your symptoms are severe, call or your local emergency number, or go to the nearest emergency room right away. As with all medications, the cost of Cymbalta can vary. To find current prices for Cymbalta in your area, check out GoodRx. The cost you find on GoodRx.
Before approving coverage for Cymbalta, your insurance company may require you to get prior authorization. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. The insurance company will review the prior authorization request and decide if the drug will be covered. If you need financial support to pay for Cymbalta, or if you need help understanding your insurance coverage, help is available.
Cymbalta is available in a generic form called duloxetine. And generics tend to cost less than brand-name drugs. To find out how the cost of duloxetine compares to the cost of Cymbalta, visit GoodRx. They may have a preference for one version or the other.
If you have questions about using other drugs with Cymbalta, talk with your doctor or pharmacist. They can review your medications and discuss treatment options with you. Cymbalta may cause harm to a fetus. However, more research is needed in this area. However, there have been a few reports of drowsiness, poor feeding , and trouble gaining weight in infants exposed to breast milk containing duloxetine.
Duloxetine is the active drug in Cymbalta. If you choose to breastfeed while taking Cymbalta, you should watch for any trouble feeding or drowsiness in your child. Together, you can weigh the risks and benefits of breastfeeding while taking the drug and discuss your other treatment and feeding options.
This drug has a boxed warning. A boxed warning alerts doctors and patients about drug effects that may be dangerous. Clinical studies have shown antidepressants such as Cymbalta increase the risk of suicidal thoughts and behaviors in children and young adults ages 24 years or younger. In people ages 65 and older, antidepressants can actually reduce this risk.
Before taking Cymbalta, talk with your doctor about your health history. Cymbalta may not be right for you if you have certain medical conditions or other factors affecting your health. These include:. When you get Cymbalta from the pharmacy, the pharmacist will add an expiration date to the label on the bottle. This date is typically 1 year from the date they dispensed the medication. The expiration date helps guarantee that the medication is effective during this time. If you have unused medication that has gone past the expiration date, talk to your pharmacist about whether you might still be able to use it.
How long a medication remains good can depend on many factors, including how and where you store the medication. Avoid storing this medication in areas where it could get damp or wet, such as bathrooms. This helps prevent others, including children and pets, from taking the drug by accident.
It also helps keep the drug from harming the environment. This article provides several useful tips on medication disposal. You can also ask your pharmacist for information on how to dispose of your medication. Cymbalta capsules are available in three strengths: 20 milligrams mg , 30 mg, and 60 mg. It can be taken with or without food. The exact mechanism by which Cymbalta treats MDD, GAD, diabetic neuropathy, fibromyalgia, and chronic musculoskeletal pain is not known. Cymbalta is classified as a serotonin-norepinephrine reuptake inhibitor SNRI.
The active drug ingredient in Cymbalta, duloxetine, inhibits neuronal serotonin and norepinephrine reuptake. To a lesser extent, duloxetine also inhibits dopamine reuptake. The effect of this on drug interactions is unknown. Food delays the time it takes for duloxetine to reach peak concentration, from 6 hours to 10 hours. However, this has no overall effect on maximum concentrations. Do not start Cymbalta in patients treated with MAOIs , including linezolid and intravenous methylene blue.
This can increase the risk of serotonin syndrome. Cymbalta is contraindicated for 14 days after stopping an MAOI intended to treat a psychiatric disorder. Obsessive compulsive disorder. These are just a few of the reasons why you might be prescribed Cymbalta. Cymbalta generic name duloxetine is a serotonin and norepinephrine reuptake inhibitor—a. That's because Prozac is an SSRI selective-serotonin reuptake inhibitor , and only affects serotonin.
Antidepressants like Cymbalta can be life-changing for the many people who use them, but like any drugs, they pose risks. The goal with antidepressants is to reduce major symptoms and then taper off after about nine months, Saltz says.
But it can be hard to quit Cymbalta when the time comes, in large part due to withdrawal symptoms. Withdrawal symptoms lasted about two weeks on average.
And the risks of staying on the drug for the long-term are unknown. The dose usually ranges from 20 mg to mg. Only your health care provider can determine the correct dose for you. It should not be chewed, crushed, or broken. Consider using a calendar, pillbox, alarm clock, or cell phone alert to help you remember to take your medication. You may also ask a family member or a friend to remind you or check in with you to be sure you are taking your medication.
If you miss a dose of duloxetine take it as soon as you remember, unless it is closer to the time of your next dose. Discuss this with your health care provider. Do not double your next dose or take more than what is prescribed. Avoid drinking alcohol or using illegal drugs while you are taking antidepressant medications.
They may decrease the benefits e. Alcohol increases the risk of liver problems with duloxetine. If an overdose occurs, call your doctor or You may need urgent medical care.
You may also contact the poison control center at Headache, nausea, diarrhea, dry mouth, decreased appetite, increased sweating, feeling nervous, restless, fatigued, sleepy or having trouble sleeping insomnia. These will often improve over the first week or two as you continue to take the medication. Sexual side effects, such as problems with orgasm or ejaculatory delay, and blood pressure increases often do not improve over time. There have been rare reports of liver failure sometimes fatal with duloxetine.
This risk is increased in those with substantial alcohol use or chronic liver disease. Orthostatic hypotension, or a drop in blood pressure when standing or getting up from sleeping, has been reported in patients taking duloxetine. The risk may be greater in patients also taking medications for high blood pressure. Increased heart rate, irregular menstrual cycle, increased frequency of urination or difficulty urinating, increased liver enzymes, teeth grinding, low sodium symptoms of low sodium levels may include headache, weakness, difficulty concentrating and remembering , angle closure glaucoma symptoms of angle closure glaucoma may include eye pain, changes in vision, swelling or redness in or around eye , serotonin syndrome symptoms may include shivering, diarrhea, confusion, severe muscle tightness, fever, seizures, and death , hypertensive crisis severely elevated blood pressure , myocardial infarction heart attack , Stevens-Johnson Syndrome rash , pancreatitis SNRI antidepressants, including duloxetine, may increase the risk of bleeding events.
Combined use of aspirin, nonsteroidal anti-inflammatory drugs e. This may include gums that bleed more easily, nose bleed, or gastrointestinal bleeding. Some cases have been life threatening. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. There is a problem with information submitted for this request. Sign up for free, and stay up-to-date on research advancements, health tips and current health topics, like COVID, plus expert advice on managing your health.
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