Hi Aly I have been taking supplements for the last 9 years for joints and energy. I was told and directed to take ith food or after.
Hope this helps. I have taken this for years and it has helped me so much! The problem is it raises my blood pressure, even with my blood pressure medicine, so I had to stop taking it. My arthritis pain was so bad I started it again, and up went my blood pressure. So I stopped again and I take MSM for pain and optimized quercetin and bromelain , taurine and a few other supplements that help arthritis and I think I have found the answer.
My blood pressure went down and no pain! I cannot afford to go to a doc. The proof is in the pudding as the old saying goes. My sis has problems with iodine so she cannot take it. I am still trying to find a safe one for her. Thank you!! The key is in the efficacy of the brand. The ingredients used, I believe, will affect the way it is absorbed. This brand has definitely worked for me — both in pain management and slowing the deterioration of cartilage.
I started after my first hip replacement having been told my other hip would be following soon. After 15 years I finally had my other hip replaced. No study will change my mind.
Have you discovered the fountain of youth? I explained about the doggy glucosamine pills and the neighbour was so very impressed with the change in Mopsy that she began taking glucosamine herself for joint stiffness. So one double-blind observation, in favour of glucosamine improving agility in an old bichon. And my neighbour reports that her knees feel much better, but she does know what she is swallowing ….
In uncontrolled studies of knee arthroscopy for osteoarthritis, about half the patients report relief from pain…. I have thru the years ran out of them or was off my routine of taking them and I have noticed more pain not only in my joints, but also start having more pain in my leg from my sciatic nerve. I first started eating gummy candies at a recommendation of my brother I had complained about my ankles bothering me in the morning when I got up.
I am not sure how long I had been eating them when one morning I did not have the problem. When I ran out, it came back. I would start again and it would go away. I can affirm there is relief for me by taking the supplements. I told countless people about my experience and they came back and thanked me for telling them. For me, however, it just plain works. Must be eating into drug manufactures profits! Have any studies been done animal?
I have a feeling that actual scientific studies have been eclipsed by testimonials. One wonders if some may even be related to the companies manufacturing said products. Excellent comment. BUT, before I started, I thoroughly researched brands and have concluded that the efficacy vary greatly from one to another. This goes to what you intimate — what exactly reaches the blood and what remains to be absorbed.
Without using the best ingredients available, the studies will always be suspect. I found glucosamine sulfate mg which I took 2 times a day. I had relief when I took them and pain when I did not. I stopped and all is good. I now live never thinking about the fall and have no limp and take no meds. I tend to recommend a collagen supplement rather than glucosamine.
While the aminos in collagen are non-essential amino acids, I think it is unlikely that all people are making enough of these compounds to serve the routine needs of the skin and gut, the cofactor needs in the case of glycine , and still have enough left over to support healing a damaged joint. Several years ago I had terrible pain in my right knee, seemingly out of the blue. I could hardly walk. I contacted the most highly rated knee surgeon in Atlanta at the time.
She made an appointment, took an x-ray, and said I was losing cartilage behind my right knee cap. Glucosamine hydrochloride, another form of glucosamine, is available as a nutritional supplement and is considered to be as effective as the sulfate form although there are fewer completed studies to review.
This hydrochloride form of glucosamine is more available for absorption into the body; therefore, a smaller dose delivers an equivalent amount in the system. Chondroitin sulfate is a larger molecule also found in cartilage. Chondroitin sulfate has been studied much less extensively, but early results show that it also seems to work as an anti-inflammatory and reduces pain.
Some laboratory studies suggest that chondroitin sulfate may slow cartilage breakdown associated with osteoarthritis and even stimulate cartilage growth. Many patients who suffer from osteoarthritis may benefit from the positive effects of taking this supplement.
The painful symptoms of osteoarthritis may appear when cartilage becomes worn, and exposed bones begin to rub together. Conventional medicine does not yet have a proven treatment to stop or slow the progression of osteoarthritis. Traditional medical treatment includes drug therapy to control the pain associated with osteoarthritis. These treatments are sometimes disappointing for physicians and patients because medications may not provide complete relief and can have unwanted side effects.
Some of these patients may be candidates for nutritional supplements like glucosamine and chondroitin sulfate. Preliminary studies show glucosamine sulfate and chondroitin sulfate to be safe and well tolerated.
Most participants in the study had mild knee pain. Those who received the prescription drug had better short-term pain relief at 6 months than those who received a placebo. Overall, those who received the supplements had no significant improvement in knee pain or function, although the investigators saw evidence of improvement in a small subgroup of patients with moderate-to-severe pain who took glucosamine and chondroitin together.
In several European studies, participants reported that their knees felt and functioned better after taking glucosamine. The study participants took a large, once-a-day dose of a preparation of glucosamine sulfate sold as a prescription drug in Europe. It may be because of differences in the types of glucosamine used glucosamine hydrochloride in the NIH study vs. More than 20 studies have looked at the effect of chondroitin on pain from knee or hip osteoarthritis.
The quality of the studies varied and so did the results. Joint Structure. For Other Parts of the Body Only a small amount of research has been done on glucosamine and chondroitin for osteoarthritis of joints other than the knee and hip. Chondroitin for osteoarthritis of the hand A 6-month trial of chondroitin in patients with severe osteoarthritis of the hand showed that it may improve pain and function. Glucosamine for osteoarthritis of the jaw One study of 45 patients with osteoarthritis of the jaw showed that those given glucosamine had less pain than those given ibuprofen.
Glucosamine for chronic low-back pain and osteoarthritis of the spine A Norwegian trial involving people with chronic low-back pain and osteoarthritis of the lower spine found that participants who received glucosamine fared the same at 6 months as those who received placebo. No serious side effects have been reported in large, well-conducted studies of people taking glucosamine, chondroitin, or both for up to 3 years.
However, glucosamine or chondroitin may interact with the anticoagulant blood-thinning drug warfarin Coumadin. A study in rats showed that long-term use of moderately large doses of glucosamine might damage the kidneys. Glucosamine might affect the way your body handles sugar, especially if you have diabetes or other blood sugar problems , such as insulin resistance or impaired glucose tolerance.
More to Consider. If your joints hurt, see your health care provider. Some diseases that cause joint pain—such as rheumatoid arthritis—may need immediate treatment.
If you take warfarin or have blood sugar problems, make sure you talk to your doctor about potential side effects if you are considering or taking glucosamine or chondroitin supplements. Help your health care providers give you better coordinated and safe care by telling them about all the health approaches you use.
Give them a full picture of what you do to manage your health. Key References. Archives of Biochemistry and Biophysics. No effect of glucosamine sulfate on osteoarthritis in the temporomandibular joints—a randomized, controlled, short-term study.
In theory, these supplements have the potential to slow cartilage deterioration in the joints, and to reduce pain in the process. In follow-up results of the study released in , these supplements improved pain and function, although no better than a placebo or the NSAID drug celecoxib. A multinational study called the MOVES trial found the combination of glucosamine and chondroitin as effective at relieving knee OA pain and swelling as celecoxib, without the side effects.
And another study found the combination helped reduce joint space narrowing--a sign of cartilage degeneration. Reviews of studies have yielded mixed results about these supplements. The difference in outcomes may be due to the variety of supplement types and doses researchers used. Studies have also differed on which of these supplements offers the greatest benefit for OA. Some find chondroitin to be superior, others favor glucosamine, while still others prefer a combination of the two.
The ideal form of glucosamine has also caused dissent in the research community. Some studies show an advantage to glucosamine sulfate; others to glucosamine hydrochloride. One study that compared the two glucosamine forms head to head found no real difference between them. Mayo Clinic researchers agree, saying that evidence supports trying glucosamine sulfate — not hydrochloride — with or without chondroitin sulfate for knee OA.
Glucosamine and chondroitin are considered safe, with no serious side effects reported in studies. However, these supplements can interact with blood thinners like warfarin Coumadin. They might also affect blood sugar levels, and one small study found they raise eye pressure, which could increase the risk for glaucoma. If you have diabetes or glaucoma, you may need to avoid these supplements, or have your doctor monitor your blood sugar levels and eye pressure more closely while you take them.
That means that there isn't strong evidence that benefits outweigh risk, but the supplement could be helpful for people with OA. Also, be patient. Get involved with the arthritis community. Every gift to the Arthritis Foundation will help people with arthritis across the U.
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